Cincinnati Children's Blog

Cincinnati Children’s team begins testing new drug for severe lung damage

Researchers at Cincinnati Children’s studied a transcription factor called FOXF1 to develop an experimental drug that one day could treat severe lung damage.

“A small molecule compound we developed efficiently stabilizes the FOXF1 protein in cell cultures and mouse lungs, and it shows promise in inhibiting lung inflammation and protecting experimental mice from lung injury,” says Vladimir Kalinichenko, MD, PhD, Pulmonary Biology and Developmental Biology.

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