Researchers find possible treatment for suppressed immunity from spine injuries
Researchers at Cincinnati Children’s and Wexner Medical Center at The Ohio State University found a possible treatment for spinal cord injury-induced immune suppression syndrome using chemogenetics. The scientists used the chemogenetics to silence the signaling transmissions from interneurons that trigger the immune system reflex.
“Infection, a consequence of immune suppression, is the leading cause of death for people with spinal cord injuries,” said Yutaka Yoshida, PhD, Developmental Biology. “Patients and mouse models of spinal injury also are subject to autonomic dysreflexia, a potentially fatal clinical syndrome marked by episodes of high blood pressure.”