Cincinnati Children's Blog

Stem Cells Should be Screened for Mitochondrial DNA Mutations Prior to Clinical Use, Study Suggests

In a recent study, researchers including Taosheng Huang, MD, PhD, director, Mitochondrial Disorders Program, found that induced pluripotent stem cell lines had elevated levels of somatic mitochondrial mutations. In Cell Stem Cell, the researchers argue that stem cells should be screened for mutations in the mitochondrial genome before they are used for clinical applications.

“Structural damages to the mtDNA genes in iPSCs will likely diminish their metabolic function in energy demanding differentiated cells and, thereby, limit their therapeutic potential and may also affect applications in disease modeling or pharmacological screening,” the authors wrote.

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